D2: insulin resistance disease is an adaptation

http://www.cardiab.com/content/15/1/17

http://www.ncbi.nlm.nih.gov/m/pubmed/25713189/

As a matter of fact insulin resistance is a very potent biomarker of cardiovascular diseases in a healthy population

Yip J, Facchini FS, Reaven GM 1998 Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab 83:2773–2776 [Abstract][Medline]

http://press.endocrine.org/doi/10.1210/jcem.86.8.7763?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&