Sugar and lung cancer in non smokers

http://cebp.aacrjournals.org/

http://www.ncbi.nlm.nih.gov/pubmed/12433720

Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites

1. Stephanie C. Melkonian1, 
2. Carrie R. Daniel1, 
3. Yuanqing Ye1, 
4. Jeanne A. Pierzynski1,
5. Jack A. Roth2, and 
6. Xifeng Wu1,*

+Author Affiliations

1. ¹Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
2. ²Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

1. ↵*Corresponding Author:
   Xifeng Wu, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Unit 1340, 1155 Pressler Boulevard, Houston, TX 77030. Phone: 713-745-2485; Fax: 713-792-4657; E-mail: xwu@mdanderson.org

Abstract

Background: Postprandial glucose (PPG) and insulin responses play a role in carcinogenesis. We evaluated the association between dietary glycemic index (GI) and glycemic load (GL), markers of carbohydrate intake and PPG, and lung cancer risk in non-Hispanic whites.

Methods: GL and GI were assessed among 1,905 newly diagnosed lung cancer cases recruited from the University of Texas MD Anderson Cancer Center (Houston, TX) and 2,413 healthy controls recruited at Kelsey-Seybold Clinics (Houston, TX). We assessed associations between quintiles of GI/GL and lung cancer risk and effect modification by various risk factors. ORs and 95% confidence intervals (CI) were estimated using multivariable logistic regression.

Results: We observed a significant association between GI [5th vs. 1st quintile (Q) OR = 1.49; 95% CI, 1.21–1.83; P_trend <0 .001="" and="" cancer="" gi="" lung="" risk="" style="border: 0px; font-size: 0.85em; font-style: inherit; font-weight: inherit; line-height: 0; margin: 0px; outline-style: none; padding: 0px; text-align: inherit;" sub="">ac

 (5th vs. 1st Q OR = 1.48; 95% CI, 1.20–1.81; P_trend = 0.001) and lung cancer risk. We observed a more pronounced association between GI and lung cancer risk among never smokers (5th vs. 1st Q OR = 2.25; 95% CI, 1.42–3.57), squamous cell carcinomas (SCC; 5th vs. 1st Q OR = 1.92; 95% CI, 1.30–2.83), and those with less than 12 years of education (5th vs. 1st Q OR = 1.75; 95% CI, 1.19–2.58, P_interaction = 0.02).

Conclusion: This study suggests that dietary GI and other lung cancer risk factors may jointly and independently influence lung cancer etiology.

Impact: Understanding the role of GI in lung cancer could inform prevention strategies and elucidate biologic pathways related to lung cancer risk. Cancer Epidemiol Biomarkers Prev; 25(3); 532–9. ©2016 AACR.


For general practitioners:
"smoking cessation, decreased radon exposure, and in patients with significant smoking history, possible enrollment in a lung cancer screening program"