The actual problem with this paper is apparently that sat fat effects on the brain needs sucrose...

https://www.sciencedirect.com/science/article/pii/S2212877817309389?via%3Dihub



"The present findings demonstrate that overconsumption of saturated fat (in combination with excess sugar) that leads to the development of DIO stimulates anxiodepressive behavior. "

Saturated high fat feeding is not high fat diet: 43% carbs, 50% fat and 7% of protein...

Very ununderstandable abstract

Abstract

Objective

The incidence of depression is significantly compounded by obesity. Obesity arising from excessive intake of high-fat food provokes anxiodepressive behaviour and elicits molecular adaptations in the nucleus accumbens (NAc), a region well-implicated in the hedonic deficits associated with depression and in the control of food-motivated behaviour. To determine the aetiology of diet-induced depression, we studied the impact of different dietary lipids on anxiodepressive behaviour and metabolic and immune outcomes and the contribution of NAcimmune activity.

Methods

Adult C57Bl/6 mice were subjected to isocaloric high-fat/high-sucrose diets (HFD), enriched in either saturated or monounsaturated fat, or a control low-fat diet (LFD). Metabolic responses, anxiodepressive behaviour, and plasma and NAc inflammatory markers were assessed after 12 weeks. In separate experiments, an adenoviral construct inhibiting IKKβ, an upstream component of the nuclear factor kappa-b (NFkB) pathway, was a priori injected into the NAc.

Results

Both HFDs resulted in obesity and hyperleptinemia; however, the saturated HFD uniquely triggered anxiety-like behaviour, behavioural despair, hyperinsulinemia, glucose intolerance, peripheral inflammation, and multiple pro-inflammatory signs in the NAc, including reactive gliosis, increased expression of cytokines, antigen-presenting markers and NFкB transcriptional activity. Selective NAc IKKβ inhibition reversed the upregulated expression of inflammatory markers, prevented anxiodepressive behavior and blunted compulsive sucrose-seeking in mice fed the saturated HFD.

Conclusions

Metabolic inflammation and NFкB-mediated neuroinflammatory responses in the NAc contribute to the expression of anxiodepressive behavior and heightened food cravings caused by a diet high in saturated fat and sugar.

Leptin from adipocytes and ghrelin from GI tract